Speeding up the translation from bench to bedside
Objective:
Improve the translational approach in research to increase the number of new treatments and prevention strategies that will become available in health care for OA patients.
Task 2.1: Technical and economic hurdles associated with the establishment and implementation of translational research models (crossing the Valley of Death).
Task 2.2: Guidelines for data collection, sampling, phenotyping, endotyping and clinical trial designs for companies bringing products targeting OA to the market to avoid common repeated failures in phase 2 and 3 clinical trials.
Task 2.3: Identification of the major challenges associated with translation from preclinical models to humans without intermediate translational models.
Task 2.4: European Consensus on Chronic Disease Self-Management Program CDSMP program for OA prevention.
Deliverables
On the 30th of April 2025, at 1pm CET, we had the WG2 Monthly Meeting that took place online.
During the meeting we had an update of the work being developed in our WG. We work in different subgroups for five manuscripts that at different stages of preparation and one project that is considering the format from manuscript or online survey. We cover different aspects of OA, from biomolecules and natural products used in disease management, to pre-clinical in vitro and in vivo models used for OA research, and on surrogate outcomes and predictive markers for knee OA development.
We are also planning a Podcast series, that will start to be recorded in the coming months, stay tuned!
Finally, we continued to discuss the possibility for a joint grant application to Horizon EU funding program.